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Silent Inflammation Check: Clarify Subclinical Inflammation • mikrooek.de

FOR MEDICAL COMMUNITY

Silent Inflammation Check

Clarify Subclinical Inflammation

Our new Silent Inflammation Check resolves chronic, subclinical inflammation that may pave the way for a whole range of diseases.

Examples are:

  • Depression and anxiety disorders
  • Metabolic syndrome
  • Obesity
  • Type 2 diabetes
  • Arteriosclerosis
  • Steatohepatitis
  • Autoimmune diseases (Multiple Sclerosis)
  • Tumour diseases

In case of a subclinical inflammation - silent inflammation - kynurenine accumulates in the serum due to an increased  activity of the enzyme indoleamine-2,3-dioxygenase(IDO). The elevated kynurenine level suppresses necessary defence reactions of the immune system ans can lead to depressive symptoms.

Silent inflammation - Which importance has the gut microbiota - part 1
The following webinar is in German.

LPS and leaky gut: reasons for a silent inflammation

Subclinical inflammation - silent inflammation - occurs when food, bacterial debris, and other foreign antigens are increasingly entering the epithelium and bloodstream. The cause is an increased permeability of the intestinal mucosa, which is also known as leaky gut syndrome.

In particular, the bacterial endotoxins - the lipopolysaccharides (LPS) - cause low-grade inflammation throughout the body. LPS is part of the cell wall of Gram-negative bacteria. If the bacteria die, the endotoxin is released from the cell wall. Not only bacteria from the gut, but also dental plaques can be the origin of an increased endotoxin input.

The body continually releases pro-inflammatory cytokines, thereby damaging the tissue long-term.

Are the concentrations of antibodies against LPS elevated the endotoxin burden is the probable reason for the silent inflammation.

However, other factors such as chronic stress and environmental toxins can cause a silent inflammation.

 

 

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