HeparCheck: elucidate endogenous liver stress
A disturbed intestinal barrier is the result of an altered microflora and / or increased permeability of the intestinal epithelium. Thus, hepatotoxins that are formed by proteolytic bacteria in the intestine or are already taken up with food can enter the enterohepatic circulation. In addition, endotoxins - lipopolysaccharides of Gram-negative bacteria - can pass through the defective intestinal mucosa and lead to latent inflammatory processes. This process is now known as metabolic endotoxemia.
Metabolic endotoxemia is not only associated with the development of chronic diseases such as diabetes, obesity and arteriosclerosis, but also leads to a creeping impairment of the liver function, which can lead to a fatty liver in the case of endotoxemia.
Endogenous liver burden by proteolytic microorganisms
The Institute of Microecology has assessed the burden of hepatotoxins using the newly developed HeparCheck:
- Iso-fatty acids serve as markers for an increased bacterial protein degradation
in the intestine.
- Zonulin and butyric acid are used to assess the permeability and the integrity of
the mucous membrane. This provides information on the inflow of hepatotoxins
into the body.
- In addition, marker organisms of the proteolytic flora and the protective flora
are enumerated. This makes it possible to assess, whether the intestinal flora
protects or damages the liver.
The HeparCheck combines various microflora and mucous membrane related parameters and thus senses increased formation and/ or increased inflow of hepatotoxins.
The results show whether there is a beginning liver burden. In this case, hepatoxic agents can be medicinal dregded before making harm. If the permeability of the mucosal surface is increased, it is wise to stabilize it.