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Detect and prove histamine intolerance • mikrooek.de


Detect and prove histamine intolerance

Histamine intolerance is a disease that has been described only in recent years. It is estimated that one to three percent of the population suffer from a histamine intolerance. Following the consumption of histamine rich foods, the affected persons exhibit allergy-like symptoms.
Classical allergy diagnostics show no results, as no immunoglobulins can be detected. This is due to the fact that histamine intolerance is characterized by a lack of the enzyme diaminooxidase (DAO) which eliminates excessive histamine.


Characteristic symptoms of a histamine intolerance are:

  • flushing,
  • nausea,
  • diarrhoea,
  • migraine headache,
  • heat sensation, and
  • dyspnoea.

The main difference between a histamine intolerance and a food allergy: in the case of a histamine intolerance, the strength of the symptoms depends on the amount of histamine added. Patients suffering from histamine intolerance should employ a histamine-poor diet.

There are several factores responsible for a DAO deficiency:     

  • Damage of enterocytes by gastrointestinal diseases
  • Competitive inhibition of DAO via drugs (e.g., ASS, NSAID, verapamil, cimetidine, ambroxol, etc.), alcohol, and biogenic amines
  • Genetic predisposition.

If the DAO is reduced in its function or activity, accumulation of extracellular histamine occurs. If the amount exceeds an individual’s tolerance, histamine-mediated symptoms will be triggered. In patients with reduced DAO activity, even small amounts of histamine can cause discomfort.

In addition, a modern diagnostic for histamine intolerance should include a faecal examination of microbial histamine generators such as Morganella morganii.

We offer the following parameters:     

  •     Quantitative histamine determination
  •     Detection of histamine-forming microorganisms
  •     Determination of diaminooxidase (DAO) activity