FOR MEDICAL COMMUNITY

Diagnosis of coeliac disease

Coeliac disease is an inherited intolerance to gluten-containing foods such as wheat, barley and rye. It leads to damage of the intestinal mucosa and to an intestinal resorption disorder. Clinical symptoms of celiac disease are dependent on the extent of mucous membrane damage in the small intestine.

In some patients, the disease manifests itself in childhood, already - mainly between the 9th and 18th month of life. In the adults the disease is much weaker, and often described as latent coeliac disease. Symptoms may be abdominal pain, recurrent diarrhea or flatulence.  

Epidemiological studies showed, that weak forms of coeliac disease are increasing in the western hemisphere. They may be found in up to 1.5% of the adult population. Since the weak forms of coeliac disease may lead to deficiencies, a diagnostic evaluation is useful. Non-treated coeliac disease increases the risk of developing non-Hodgkin's lymphoma. Furthermore, the risk of colorectal cancer may increase.

If a coeliac disease is suspected, a faecal test is recommended. To confirm the result a blood test is mandatory.

Reference range:

Anti-gliadin >150 mU/g Stool
Anti-transglutaminase > 150 mU/g Stool