Coeliac disease: Elucidate wheat-dependend diseases
In case of diet-related disorders like abdominal pain, flatulences or stuffed feeling, quickly the suspicion raises that the reason is a wheat incompatibility and the contained gluten.
Often, the persons concerned abstain from bread, noodles and pizza. Prior to go on such a diet it should be elucideted whether the symptoms are actually diet-related and how far the wheat is really involved.
In addition to the serious clinical picture of coeliac disease more and more the wheat allergy or a wheat sensitivity come to the fore. Lectins which protect the plants against predators like for example wheat germ agglutinin (WGA) can induce disorders in the human body.
Our gradual concept in case of wheat-related disorders:
Stage 1: Elucidation of coeliac disease
- Anti-transglutaminase antibodies (IgA/IgG)
- Anti-gliadin antibodies (IgA/IgG)
- New: Genetic testing of the coeliac predisposition
Elucidation whether the gene for the autoimmune component is present.
Stage 2: Elucidation of a wheat allergy
- Type I allergy (IgE)
- Type III allergy (IgG1-3)
Stage 3: Sensitivity against wheat lectin (independenly from gluten)
- New: Wheat germ agglutinin antibodies (IgG)
Diagnosis of coeliac disease
Coeliac disease is an inherited intolerance to gluten-containing foods such as wheat, barley and rye. It leads to damage of the intestinal mucosa and to an intestinal resorption disorder. Clinical symptoms of celiac disease are dependent on the extent of mucous membrane damage in the small intestine.
In some patients, the disease manifests itself in childhood, already - mainly between the 9th and 18th month of life. In the adults the disease is much weaker, and often described as latent coeliac disease. Symptoms may be abdominal pain, recurrent diarrhea or flatulence.
Epidemiological studies showed, that weak forms of coeliac disease are increasing in the western hemisphere. They may be found in up to 1.5% of the adult population. Since the weak forms of coeliac disease may lead to deficiencies, a diagnostic evaluation is useful. Non-treated coeliac disease increases the risk of developing non-Hodgkin's lymphoma. Furthermore, the risk of colorectal cancer may increase.
If a coeliac disease is suspected, a faecal test is recommended. To confirm the result a blood test is mandatory.
Anti-gliadin >150 mU/g Stool
Anti-transglutaminase > 150 mU/g Stool
The prevalence of coeliac disease in recent years is probably not only due to gluten, but to amylase trypsin inhibitors (ATIs), which are associated with gluten-containing products. These proteins activate the innate immune system, which releases inflammatory substances. The diagnosis of wheat sensitivity is based on the exclusion of a wheat allergy and coeliac disease. A wheat sensitivity is verified if the symptoms improve with a wheat-free diet and if they deteriorate with provocation diet.
Anna Sapone et al. describe diagnosis algorithms for wheat sensitivity (diagram on page 9).